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How to finance development of a drug that failed commercial assessment
Five models. None complete. One promising direction.
May 10
•
Eswar Krishnan, MD
3
The Site That Never Enrolled: What Clinical Operations Gets Wrong About Early Signals
*Dynamic optimization for clinical operations leaders — the case for acting before certainty arrives*
May 5
•
Eswar Krishnan, MD
1
Post 01: Before You Spend a Dollar on Quantum, Answer This
Three executives at three pharmas got the same quantum vendor pitch last quarter. One signed a three-year deal. One asked for a six-month pilot. One…
May 5
•
Eswar Krishnan, MD
1
1
April 2026
Quantum for Drug development : A Series Introduction
The Decision This Series Forces
Apr 29
•
Eswar Krishnan, MD
6
1
1
Your Child Isn’t Being Difficult. Their Immune System Is Talking to Their Brain.
A physician’s guide to what food allergies actually do to children — the data most families never hear, the neuroscience behind food aversion, and where…
Apr 14
•
Eswar Krishnan, MD
1
1
The WSJ piece on China’s biotech rise is worth reading — critically.
WSJ article [paywall]
Apr 14
•
Eswar Krishnan, MD
1
When one patient is the whole trial
Approximately 7,000 rare diseases are known. Fewer than 5% have an approved treatment. Gene therapy has started to change that equation—not for…
Apr 13
•
Eswar Krishnan, MD
3
2
The Flower That Runs the World’s Most Dangerous Pharmacy
How a roadside weed became the original heart drug — and is now turning up in cancer laboratories with a completely different job description
Apr 12
•
Eswar Krishnan, MD
1
3
The Tyranny of Simple: Seven Centuries of Wrong
AlphaFold has more trainable parameters than there are synaptic connections in a fruit fly’s brain.
Apr 11
•
Eswar Krishnan, MD
1
2
Is Biology Quantum? The Answer Is Getting Harder to Dodge
What Enzymes Know That Models Don't
Apr 11
•
Eswar Krishnan, MD
1
1
March 2026
The Mandelbrot Boundary: The Non-Linear Geometry of Clinical Trial Failure
Why your trial is an iterative dynamical system, not a spreadsheet
Mar 30
•
Eswar Krishnan, MD
1
2
Your Trial Is Not Behind Schedule. It Is in the Wrong Place.
The geometrical principles of operational failure in clinical development
Mar 19
•
Eswar Krishnan, MD
1
4
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