Archive - Drug Development Executive

Taltz+Zepbound : When Obesity Becomes a PK Problem

We Got the Synergy Story Backwards? Everyone: "GLP-1 + ixekizumab = immune synergy." Data: "Actually, ~70% of the benefit looks like weight loss fixing…

11 hrs ago

Would You Market a Drug You Can’t Explain?

(I probably will)

Feb 23 • Eswar Krishnan, MD

CAR-T for Autoimmune Disease: A Safety Reckoning Is Coming – and the Field Is Not Ready

Graph showing adverse event rates in CAR-T therapy for lupus

Feb 9 • Eswar Krishnan, MD

The unbearable lightness of AI written posts

There’s a little theatre that plays out on Substack, LinkedIn and other social media.

Feb 7 • Eswar Krishnan, MD

January 2026

Atherosclerotic Plaque as a Lymphoid Organ

An introduction

Jan 15 • Eswar Krishnan, MD

Forget CRP. Think Tregs

Low-Dose IL-2 Reduces Arterial Inflammation in ACS—Without Touching CRP

Jan 14 • Eswar Krishnan, MD

Dear Medical Writing: It's Not You, It's the Algorithm

Dear Medical Writing,

Jan 13 • Eswar Krishnan, MD

How to Turn a $200M Biosimilar Into a $1B Franchise

The formulation play that created a 20-year monopoly

Jan 8 • Eswar Krishnan, MD

Bispecifics: Synergy That Can Be Modeled, Not Easily Verified

A case study of a α4β7 × TL1A bispecific

Jan 8 • Eswar Krishnan, MD

The Algorithm in the Corner Office

Business Development for Medical Leaders Series – Part 1

Jan 3 • Eswar Krishnan, MD

July 2025

State Of The Art in SLE: For Biotech CMOs and CSOs

Jul 18, 2025 • Eswar Krishnan, MD

45:46

Is a pIND meeting always a prerequisite for success, or is it sometimes a bottleneck?

Jul 16, 2025 • Eswar Krishnan, MD

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