Drug Development Executive

Drug Development Executive

Basic/Translational Sciences

Zasocitinib: NextGen Allosteric TYK2 Inhibitor—Is the Hype Justified?

Eswar Krishnan, MD's avatar
Eswar Krishnan, MD
Jun 03, 2025
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Commentary on Mehrotra S,………, McInnes IB, Pharmacological Characterization of Zasocitinib (TAK-279): An Oral, Highly Selective and Potent Allosteric TYK2 Inhibitor, The Journal of Investigative Dermatology (2025), doi: https://doi.org/10.1016/j.jid.2025.05.014.

a) Rationale, Objectives, and Novelty

The rationale for the Mehrotra et al. study stems from th…

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