Interferon Regulatory Factor 7 as drug development target for SLE?

Selectively reduces autoantibody producing plasma cells and downregulates type I interferon without increasing infection risk

Interferon Regulatory Factor 7 (IRF7) plays a crucial role in driving spontaneous autoimmune germinal center and plasma cell checkpoints, while being dispensable for normal responses to foreign antigens. This understanding has significant implications for the treatment of Systemic Lupus Erythematosus (SLE).

This specificity makes IRF7 an attractive thera…