Drug Development Executive

Drug Development Executive

How to Turn a $200M Biosimilar Into a $1B Franchise

The formulation play that created a 20-year monopoly

Eswar Krishnan, MD's avatar
Eswar Krishnan, MD
Jan 08, 2026
∙ Paid

Most biosimilar companies are playing a losing game.

They spend 8-10 years and $100-200M developing a product that immediately enters a race to the bottom. They compete on 5% margin differences. Meanwhile, originators maintain their infusion center relationships and patient loyalty programs. The biosimilar manufacturers fight over scraps.

User's avatar

Continue reading this post for free, courtesy of Eswar Krishnan, MD.

Or purchase a paid subscription.
© 2026 Eswar Krishnan · Privacy ∙ Terms ∙ Collection notice
Start your SubstackGet the app
Substack is the home for great culture