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Drug Development Executive
Forget Basic AI: Why RAG-LLMs Beat ChatGPT for Faster and Compliant Clinical Trial Docs

Forget Basic AI: Why RAG-LLMs Beat ChatGPT for Faster and Compliant Clinical Trial Docs

Spolier alert: NotebookLM is better than Gemini for (re)generating clinical trial documents

Eswar Krishnan, MD's avatar
Eswar Krishnan, MD
May 27, 2025
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Drug Development Executive
Drug Development Executive
Forget Basic AI: Why RAG-LLMs Beat ChatGPT for Faster and Compliant Clinical Trial Docs
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We all know the drill: protocols, consents, reports – it's a mountain, and writing it is a major bottleneck. LLMs like ChatGPT seemed like a breakthrough, but let's be honest, there were real concerns about quality. So, can AI really handle this?

Nigel Markey and colleagues put GPT-4 through its paces, asking it to write protocol sections (endpoints & el…

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