FAQ: CNS Penetration of drugs

An Introduction of Barriers, Mechanisms, and Emerging Strategies in Neuropharmacology

1. Why is Reaching the Brain So Crucial, Yet So Difficult?

Treating central nervous system (CNS) disorders effectively is a huge task in medicine. A key problem is getting drugs to their brain and spinal cord targets in enough quantity. The CNS has strong natural protections. These barriers stop most medicines from entering.

As a result, many promising ne…