Drugging the Master Regulators: A New Era for Targeting STAT Transcription Factors

The clinical paradox of STAT signaling, where hyperactivity drives autoimmunity while insufficiency causes fatal immunodeficiency, offers a unique blueprint for precision drug development.

The JAK-STAT signaling pathway is a fundamental signaling cascade whose disruption is the etiology of numerous genetically defined human diseases. This evolutionarily conserved system serves as the primary conduit for signals from nearly 60 cytokines, interferons, and growth factors, translating extracellular commands into precise transcriptional progra…