<?xml version="1.0" encoding="UTF-8"?><rss xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:content="http://purl.org/rss/1.0/modules/content/" xmlns:atom="http://www.w3.org/2005/Atom" version="2.0" xmlns:itunes="http://www.itunes.com/dtds/podcast-1.0.dtd" xmlns:googleplay="http://www.google.com/schemas/play-podcasts/1.0"><channel><title><![CDATA[Drug Development Executive: Policy]]></title><description><![CDATA[Dive into the messy, fascinating world of policy, where regulatory decisions, political pressures, and economic realities collide to shape our lives. From vaccine approvals to market rules, we unpack how leaders balance science, power, and money. Expect clear, no-nonsense takes on why policies matter, who’s accountable, and how they impact you, whether it’s your health or your wallet. Join us to explore the stakes, question groupthink, and hold decision-makers’ feet to the fire when it counts.]]></description><link>https://www.drugdevelop.com/s/policy</link><image><url>https://substackcdn.com/image/fetch/$s_!7dLO!,w_256,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Faca5e80b-d1f3-41b0-8379-73935f28e18d_960x960.png</url><title>Drug Development Executive: Policy</title><link>https://www.drugdevelop.com/s/policy</link></image><generator>Substack</generator><lastBuildDate>Sat, 11 Apr 2026 05:22:00 GMT</lastBuildDate><atom:link href="https://www.drugdevelop.com/feed" rel="self" type="application/rss+xml"/><copyright><![CDATA[Eswar Krishnan]]></copyright><language><![CDATA[en]]></language><webMaster><![CDATA[drugdevelop@substack.com]]></webMaster><itunes:owner><itunes:email><![CDATA[drugdevelop@substack.com]]></itunes:email><itunes:name><![CDATA[Eswar Krishnan, MD]]></itunes:name></itunes:owner><itunes:author><![CDATA[Eswar Krishnan, MD]]></itunes:author><googleplay:owner><![CDATA[drugdevelop@substack.com]]></googleplay:owner><googleplay:email><![CDATA[drugdevelop@substack.com]]></googleplay:email><googleplay:author><![CDATA[Eswar Krishnan, MD]]></googleplay:author><itunes:block><![CDATA[Yes]]></itunes:block><item><title><![CDATA[The unbearable lightness of AI written posts]]></title><description><![CDATA[There&#8217;s a little theatre that plays out on Substack, LinkedIn and other social media.]]></description><link>https://www.drugdevelop.com/p/the-unbearable-lightness-of-ai-written</link><guid isPermaLink="false">https://www.drugdevelop.com/p/the-unbearable-lightness-of-ai-written</guid><dc:creator><![CDATA[Eswar Krishnan, MD]]></dc:creator><pubDate>Sat, 07 Feb 2026 23:46:14 GMT</pubDate><enclosure url="https://images.unsplash.com/photo-1684487747720-1ba29cda82f8?crop=entropy&amp;cs=tinysrgb&amp;fit=max&amp;fm=jpg&amp;ixid=M3wzMDAzMzh8MHwxfHNlYXJjaHw3fHxjaGF0JTIwZ3B0fGVufDB8fHx8MTc3MDUwNzQ5OHww&amp;ixlib=rb-4.1.0&amp;q=80&amp;w=1080" length="0" type="image/jpeg"/><content:encoded><![CDATA[<div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://images.unsplash.com/photo-1684487747720-1ba29cda82f8?crop=entropy&amp;cs=tinysrgb&amp;fit=max&amp;fm=jpg&amp;ixid=M3wzMDAzMzh8MHwxfHNlYXJjaHw3fHxjaGF0JTIwZ3B0fGVufDB8fHx8MTc3MDUwNzQ5OHww&amp;ixlib=rb-4.1.0&amp;q=80&amp;w=1080" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://images.unsplash.com/photo-1684487747720-1ba29cda82f8?crop=entropy&amp;cs=tinysrgb&amp;fit=max&amp;fm=jpg&amp;ixid=M3wzMDAzMzh8MHwxfHNlYXJjaHw3fHxjaGF0JTIwZ3B0fGVufDB8fHx8MTc3MDUwNzQ5OHww&amp;ixlib=rb-4.1.0&amp;q=80&amp;w=1080 424w, https://images.unsplash.com/photo-1684487747720-1ba29cda82f8?crop=entropy&amp;cs=tinysrgb&amp;fit=max&amp;fm=jpg&amp;ixid=M3wzMDAzMzh8MHwxfHNlYXJjaHw3fHxjaGF0JTIwZ3B0fGVufDB8fHx8MTc3MDUwNzQ5OHww&amp;ixlib=rb-4.1.0&amp;q=80&amp;w=1080 848w, https://images.unsplash.com/photo-1684487747720-1ba29cda82f8?crop=entropy&amp;cs=tinysrgb&amp;fit=max&amp;fm=jpg&amp;ixid=M3wzMDAzMzh8MHwxfHNlYXJjaHw3fHxjaGF0JTIwZ3B0fGVufDB8fHx8MTc3MDUwNzQ5OHww&amp;ixlib=rb-4.1.0&amp;q=80&amp;w=1080 1272w, https://images.unsplash.com/photo-1684487747720-1ba29cda82f8?crop=entropy&amp;cs=tinysrgb&amp;fit=max&amp;fm=jpg&amp;ixid=M3wzMDAzMzh8MHwxfHNlYXJjaHw3fHxjaGF0JTIwZ3B0fGVufDB8fHx8MTc3MDUwNzQ5OHww&amp;ixlib=rb-4.1.0&amp;q=80&amp;w=1080 1456w" sizes="100vw"><img src="https://images.unsplash.com/photo-1684487747720-1ba29cda82f8?crop=entropy&amp;cs=tinysrgb&amp;fit=max&amp;fm=jpg&amp;ixid=M3wzMDAzMzh8MHwxfHNlYXJjaHw3fHxjaGF0JTIwZ3B0fGVufDB8fHx8MTc3MDUwNzQ5OHww&amp;ixlib=rb-4.1.0&amp;q=80&amp;w=1080" width="3840" 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srcset="https://images.unsplash.com/photo-1684487747720-1ba29cda82f8?crop=entropy&amp;cs=tinysrgb&amp;fit=max&amp;fm=jpg&amp;ixid=M3wzMDAzMzh8MHwxfHNlYXJjaHw3fHxjaGF0JTIwZ3B0fGVufDB8fHx8MTc3MDUwNzQ5OHww&amp;ixlib=rb-4.1.0&amp;q=80&amp;w=1080 424w, https://images.unsplash.com/photo-1684487747720-1ba29cda82f8?crop=entropy&amp;cs=tinysrgb&amp;fit=max&amp;fm=jpg&amp;ixid=M3wzMDAzMzh8MHwxfHNlYXJjaHw3fHxjaGF0JTIwZ3B0fGVufDB8fHx8MTc3MDUwNzQ5OHww&amp;ixlib=rb-4.1.0&amp;q=80&amp;w=1080 848w, https://images.unsplash.com/photo-1684487747720-1ba29cda82f8?crop=entropy&amp;cs=tinysrgb&amp;fit=max&amp;fm=jpg&amp;ixid=M3wzMDAzMzh8MHwxfHNlYXJjaHw3fHxjaGF0JTIwZ3B0fGVufDB8fHx8MTc3MDUwNzQ5OHww&amp;ixlib=rb-4.1.0&amp;q=80&amp;w=1080 1272w, https://images.unsplash.com/photo-1684487747720-1ba29cda82f8?crop=entropy&amp;cs=tinysrgb&amp;fit=max&amp;fm=jpg&amp;ixid=M3wzMDAzMzh8MHwxfHNlYXJjaHw3fHxjaGF0JTIwZ3B0fGVufDB8fHx8MTc3MDUwNzQ5OHww&amp;ixlib=rb-4.1.0&amp;q=80&amp;w=1080 1456w" sizes="100vw" fetchpriority="high"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a><figcaption class="image-caption">Photo by <a href="https://unsplash.com/@maria_shalabaieva">Mariia Shalabaieva</a> on <a href="https://unsplash.com">Unsplash</a></figcaption></figure></div><p>There&#8217;s a little theatre that plays out on Substack, LinkedIn and other social media. A tidy post appears&#8212;hint: correct use of oxford commas&#8212;and almost on cue someone comments: &#8220;This sounds like AI.&#8221; The tone implies a sting operation: the grammar is too clean, the paragraphs too disciplined, the culprit surely silicon.</p><p>Since when did coherent prose become suspicious behaviour?</p><div class="subscription-widget-wrap-editor" data-attrs="{&quot;url&quot;:&quot;https://www.drugdevelop.com/subscribe?&quot;,&quot;text&quot;:&quot;Subscribe&quot;,&quot;language&quot;:&quot;en&quot;}" data-component-name="SubscribeWidgetToDOM"><div class="subscription-widget show-subscribe"><div class="preamble"><p class="cta-caption">Drug Development Executive is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.</p></div><form class="subscription-widget-subscribe"><input type="email" class="email-input" name="email" placeholder="Type your email&#8230;" tabindex="-1"><input type="submit" class="button primary" value="Subscribe"><div class="fake-input-wrapper"><div class="fake-input"></div><div class="fake-button"></div></div></form></div></div><p>Somewhere along the way, &#8220;authentic&#8221; got quietly redefined as &#8220;unfiltered.&#8221;</p><p>Typos became personality. Rambling and raging turned into sincerity.</p><p>We began treating rough edges as proof of life.</p><p>Is the only honest song the one performed out of tune?</p><p>It&#8217;s charming in its way, like old cassette hiss (remember the SONY Walkman?).</p><p>But must every post sound like a live rehearsal?</p><p>A rude question: Are we defending authenticity&#8212;or defending the old inefficiencies that made us feel special?For years, first drafts were expensive in time and ego. That effort conferred a little halo: &#8220;I suffered for these sentences; kindly clap.&#8221; Now, with a single nudge, a language model can take your thought from muddy to presentable. The halo slips, and we call the polish &#8220;fake.&#8221;</p><p>But authenticity was never about the presence or absence of mistakes. It was about the presence of self. A post feels human when there&#8217;s a recognisable mind behind it: a choice made, a risk taken, a detail only you could supply. Whether the comma arrives by your hand or with a bit of algorithmic help is frankly none of the reader&#8217;s concern. They want clarity; they care who&#8217;s speaking; they don&#8217;t mind who wrote the script.</p><blockquote><p>Do you think President Obama wrote all the soaring speeches he gave?</p></blockquote><p>&#8220;But AI posts feel robotic,&#8221; people say. Sometimes they do. Then again, many human posts feel robotic too&#8212;parades of well-meaning platitudes.</p><blockquote><p>The real offence isn&#8217;t the polish; it&#8217;s emptiness.</p></blockquote><p>When a post has no friction, no specificity, no argument, it is humbug. Whether typed by a monk with a quill or a model with an NVDA Hopper GPU.</p><p>This is hardly the first time presentation tools made us anxious about &#8220;realness.&#8221; We fretted at print, then telephones, then radio, then the web, and yet somehow the human voice kept smuggling itself through.</p><p>A small confession: we are sentimental about creative suffering. We love the myth of the writer battling the page like a wrestler in a dusty akhada. It flatters the rest of us when our own drafts look scruffy; at least we are &#8220;real.&#8221;</p><blockquote><p>So what is the bottomline? AI is here to stay. DEAL WITH IT !. </p><p>If you&#8217;re still uneasy, try this framing: AI doesn&#8217;t diminish writing; it exposes it.</p></blockquote><p>AI writing does all of us a great service by leveling the playing field. By removing the role of writing aesthetics, it allows concepts to be judged for their truth.</p><p>Food to be judged by smell, taste, and nutritional value- not by visual presentation</p><p>It brings the idea to the front and asks, politely but firmly, &#8220;Is there anything here?&#8221; If the answer is no, the gloss won&#8217;t rescue it. If the answer is yes, the gloss helps it land. That is uncomfortable for anyone who relies on visible effort as a substitute for visible thought. It is also, modestly put, progress.</p><p>If you need a rule of thumb, make it this: Soul belongs to the writer; shine can come from anywhere. If you bring only shine, the post glides across the feed and vanishes. If you bring only soul and refuse any shine, the post may trip over its own shoelaces before it reaches a reader. But if you bring a real idea and allow a little polish to help it arrive on time, full marks. The reader is served, the conversation moves, and the platform becomes slightly less of a fish market.</p><p>A final, mildly naughty question to leave hanging in the air: if you can have an authentic thought and a clear sentence, why insist they travel in separate compartments? The muse does not award extra credit for split ends. She cares that you brought something only you could bring.</p><p>So yes&#8212;boo the emptiness. Applaud the clarity. And if the clarity arrives with a touch of robot polish, please adjust. The human inside the words is still the one wearing the shirt.</p><div class="subscription-widget-wrap-editor" data-attrs="{&quot;url&quot;:&quot;https://www.drugdevelop.com/subscribe?&quot;,&quot;text&quot;:&quot;Subscribe&quot;,&quot;language&quot;:&quot;en&quot;}" data-component-name="SubscribeWidgetToDOM"><div class="subscription-widget show-subscribe"><div class="preamble"><p class="cta-caption">Drug Development Executive is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.</p></div><form class="subscription-widget-subscribe"><input type="email" class="email-input" name="email" placeholder="Type your email&#8230;" tabindex="-1"><input type="submit" class="button primary" value="Subscribe"><div class="fake-input-wrapper"><div class="fake-input"></div><div class="fake-button"></div></div></form></div></div>]]></content:encoded></item><item><title><![CDATA[Rezpeg and the Art of the Immune Braking ]]></title><description><![CDATA[Helping immune system self-police]]></description><link>https://www.drugdevelop.com/p/a-saga-rezpeg-and-the-art-of-the</link><guid isPermaLink="false">https://www.drugdevelop.com/p/a-saga-rezpeg-and-the-art-of-the</guid><dc:creator><![CDATA[Eswar Krishnan, MD]]></dc:creator><pubDate>Wed, 25 Jun 2025 15:13:46 GMT</pubDate><enclosure url="https://substackcdn.com/image/fetch/$s_!GQls!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F55a02d2a-7632-4b7f-8cdd-e4d2f93fe866_5184x3456.jpeg" length="0" type="image/jpeg"/><content:encoded><![CDATA[<div class="pullquote"><p><strong>Note: I have no conflicts of interest with Nektar</strong></p></div><p><strong>Autoimmune diseases</strong>, pathologically characterized by the immune system's aberrant recognition and assault upon autologous tissues, represent intricate and multifactorial disorders. These conditions frequently arise from a dysfunctional interplay or compromised efficacy of <strong>intrinsic immunoregulatory mechan&#8230;</strong></p>
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   ]]></content:encoded></item><item><title><![CDATA[Mercury in vaccines: You be the judge.]]></title><description><![CDATA[PS: Have you heard of any heavy metal being declared as safe for humans?]]></description><link>https://www.drugdevelop.com/p/mercury-in-vaccines-you-be-the-judge</link><guid isPermaLink="false">https://www.drugdevelop.com/p/mercury-in-vaccines-you-be-the-judge</guid><dc:creator><![CDATA[Eswar Krishnan, MD]]></dc:creator><pubDate>Wed, 25 Jun 2025 13:12:18 GMT</pubDate><enclosure url="https://substackcdn.com/image/fetch/$s_!NHyh!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F39a7ee67-6f30-448b-ab91-85ad8bd9105f_1280x720.jpeg" length="0" type="image/jpeg"/><content:encoded><![CDATA[<h3><strong>Here are the facts:</strong></h3><p>The concern stems from mercury, a known neurotoxin. Thiomersal, used in some vaccines as a preservative, contains ethylmercury. This is a critical distinction from methylmercury. Methylmercury is the form found in contaminated fish and is known to cause severe neurological damage.</p><div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!NHyh!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F39a7ee67-6f30-448b-ab91-85ad8bd9105f_1280x720.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!NHyh!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F39a7ee67-6f30-448b-ab91-85ad8bd9105f_1280x720.jpeg 424w, https://substackcdn.com/image/fetch/$s_!NHyh!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F39a7ee67-6f30-448b-ab91-85ad8bd9105f_1280x720.jpeg 848w, https://substackcdn.com/image/fetch/$s_!NHyh!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F39a7ee67-6f30-448b-ab91-85ad8bd9105f_1280x720.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!NHyh!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F39a7ee67-6f30-448b-ab91-85ad8bd9105f_1280x720.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!NHyh!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F39a7ee67-6f30-448b-ab91-85ad8bd9105f_1280x720.jpeg" width="1280" height="720" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/39a7ee67-6f30-448b-ab91-85ad8bd9105f_1280x720.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:720,&quot;width&quot;:1280,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:null,&quot;alt&quot;:null,&quot;title&quot;:null,&quot;type&quot;:null,&quot;href&quot;:null,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:null,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="" srcset="https://substackcdn.com/image/fetch/$s_!NHyh!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F39a7ee67-6f30-448b-ab91-85ad8bd9105f_1280x720.jpeg 424w, https://substackcdn.com/image/fetch/$s_!NHyh!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F39a7ee67-6f30-448b-ab91-85ad8bd9105f_1280x720.jpeg 848w, https://substackcdn.com/image/fetch/$s_!NHyh!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F39a7ee67-6f30-448b-ab91-85ad8bd9105f_1280x720.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!NHyh!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F39a7ee67-6f30-448b-ab91-85ad8bd9105f_1280x720.jpeg 1456w" sizes="100vw" fetchpriority="high"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><h3><strong>PK- Toxikinetics is the main reason why mercury in vacc&#8230;</strong></h3>
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   ]]></content:encoded></item><item><title><![CDATA[Dr Atkins and the Hubris of Medical Establishment]]></title><description><![CDATA[An apology is owed]]></description><link>https://www.drugdevelop.com/p/dr-atkins-and-the-hubris-of-medical</link><guid isPermaLink="false">https://www.drugdevelop.com/p/dr-atkins-and-the-hubris-of-medical</guid><dc:creator><![CDATA[Eswar Krishnan, MD]]></dc:creator><pubDate>Mon, 23 Jun 2025 19:04:30 GMT</pubDate><enclosure url="https://substackcdn.com/image/fetch/$s_!i26p!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0e34c20e-c21e-44ca-b353-709e2792f90f_2400x1350.png" length="0" type="image/jpeg"/><content:encoded><![CDATA[<p>Remember the Atkins diet? For many, it conjures images of endless bacon, butter, and a strict ban on anything that even <em>looked</em> like a carb. It was the diet that famously told you to "eat the hamburger and throw away the bun," a mantra that simultaneously thrilled and horrified. For decades, Dr. Robert Atkins, the cardiologist behind this revolutionary (&#8230;</p>
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          <a href="https://www.drugdevelop.com/p/dr-atkins-and-the-hubris-of-medical">
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   ]]></content:encoded></item><item><title><![CDATA[African Americans: Yes for Patriotism. Meh! for Clinical Research participation. ]]></title><description><![CDATA[Juneteenth is a day for reflection and understanding for all Americans so that we may strive to be better citizens and a better society.]]></description><link>https://www.drugdevelop.com/p/african-americans-yes-for-patriotism</link><guid isPermaLink="false">https://www.drugdevelop.com/p/african-americans-yes-for-patriotism</guid><dc:creator><![CDATA[Eswar Krishnan, MD]]></dc:creator><pubDate>Thu, 19 Jun 2025 12:48:44 GMT</pubDate><enclosure url="https://substackcdn.com/image/fetch/$s_!7dLO!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Faca5e80b-d1f3-41b0-8379-73935f28e18d_960x960.png" length="0" type="image/jpeg"/><content:encoded><![CDATA[<p>Juneteenth is a day for reflection and  understanding for all Americans so that we may strive to be better citizens and a better society.  Juneteenth is not about grievences&#8211; rather it is about how, as an imperfect country, we learn from the past, reinforce the principles behind the emancipation proclamation. It can also be a day of reflection on why we&#8230;</p>
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          <a href="https://www.drugdevelop.com/p/african-americans-yes-for-patriotism">
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   ]]></content:encoded></item><item><title><![CDATA[A Call to FDA Leadership: Let's Modernize Clinical Trials to Finally Tackle Cancer Prevention]]></title><description><![CDATA[Our shared goal is to reduce the burden of cancer.]]></description><link>https://www.drugdevelop.com/p/a-call-to-fda-leadership-lets-modernize</link><guid isPermaLink="false">https://www.drugdevelop.com/p/a-call-to-fda-leadership-lets-modernize</guid><dc:creator><![CDATA[Eswar Krishnan, MD]]></dc:creator><pubDate>Mon, 16 Jun 2025 10:06:23 GMT</pubDate><enclosure url="https://substackcdn.com/image/fetch/$s_!yHZE!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd98960a2-4f9f-4261-a973-3f284613fd28_1280x1280.png" length="0" type="image/jpeg"/><content:encoded><![CDATA[<p>Our shared goal is to reduce the burden of cancer. While treatment has advanced, true victory lies in prevention. In the crucial arena of <strong>primary prevention for high-risk individuals and prevention of secondary cancers</strong>, our current clinical trial models are failing. We face a logistical and economic impasse that requires a strategic modernization of our&#8230;</p>
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          <a href="https://www.drugdevelop.com/p/a-call-to-fda-leadership-lets-modernize">
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   ]]></content:encoded></item><item><title><![CDATA[The Metric Mirage: ]]></title><description><![CDATA[Are We Measuring Our Way to Mediocrity in Healthcare and Drug Development?]]></description><link>https://www.drugdevelop.com/p/the-metric-mirage</link><guid isPermaLink="false">https://www.drugdevelop.com/p/the-metric-mirage</guid><dc:creator><![CDATA[Eswar Krishnan, MD]]></dc:creator><pubDate>Fri, 06 Jun 2025 10:20:23 GMT</pubDate><enclosure url="https://substackcdn.com/image/fetch/$s_!yHZE!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd98960a2-4f9f-4261-a973-3f284613fd28_1280x1280.png" length="0" type="image/jpeg"/><content:encoded><![CDATA[<p></p><p>As a physician who has spent decades at the bedside and an equal amount of time navigating the intricate world of drug development, I&#8217;ve seen laudable intentions curdle into counterproductive realities. One of the most pervasive and, frankly, exasperating trends is our collective obsession with quantifying <em>everything</em> in healthcare. From the physician's &#8230;</p>
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   ]]></content:encoded></item><item><title><![CDATA[AI supported Drug Approvals at the FDA: What drug developers need to know today ]]></title><description><![CDATA[I wanted to share a quick note: while I typically skip citations in my blogs, I&#8217;m making an exception this time!]]></description><link>https://www.drugdevelop.com/p/ai-supported-drug-approvals-at-the</link><guid isPermaLink="false">https://www.drugdevelop.com/p/ai-supported-drug-approvals-at-the</guid><dc:creator><![CDATA[Eswar Krishnan, MD]]></dc:creator><pubDate>Thu, 29 May 2025 13:53:58 GMT</pubDate><enclosure url="https://substackcdn.com/image/fetch/$s_!yHZE!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd98960a2-4f9f-4261-a973-3f284613fd28_1280x1280.png" length="0" type="image/jpeg"/><content:encoded><![CDATA[<div class="pullquote"><p>I<strong>&nbsp;wanted to share a quick note: while I typically skip citations in my blogs, I&#8217;m  making an exception this time! Why, you ask? It's because many of my sources come from websites that might change their content over time.</strong></p></div>
      <p>
          <a href="https://www.drugdevelop.com/p/ai-supported-drug-approvals-at-the">
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   ]]></content:encoded></item><item><title><![CDATA[Understanding How Regulators View Internet of Things and Digital Health Technology]]></title><description><![CDATA[A Regulatory Map for Digital Trials]]></description><link>https://www.drugdevelop.com/p/understanding-how-regulators-view</link><guid isPermaLink="false">https://www.drugdevelop.com/p/understanding-how-regulators-view</guid><dc:creator><![CDATA[Eswar Krishnan, MD]]></dc:creator><pubDate>Tue, 27 May 2025 22:13:24 GMT</pubDate><enclosure url="https://substackcdn.com/image/fetch/$s_!yHZE!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd98960a2-4f9f-4261-a973-3f284613fd28_1280x1280.png" length="0" type="image/jpeg"/><content:encoded><![CDATA[<p>The clinical trial revolution, driven by the Internet of Things (IoT) and Digital Health Technologies (DHTs), is expanding globally. We're seeing a fundamental shift towards continuous, real-world data collection and patient-centric Decentralized Clinical Trials (DCTs). But as these innovations cross borders, how are key regulatory bodies like the FDA, &#8230;</p>
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          <a href="https://www.drugdevelop.com/p/understanding-how-regulators-view">
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